Urinary excretion of olive oil phenols and their metabolites in humans

摘要: We have recently demonstrated, in humans, the bioavailability of hydroxytyrosol (3,4-dihydroxyphenylethanol; HT), one major antioxidant components virgin olive oil. In particular, we reported that this compound is present lipoproteins involved atherosclerotic processes and excreted urine mainly as glucuronide-conjugate. The aim study was to elucidate, metabolic fate HT after ingestion After administration oil, 24-hour collections healthy volunteers were prepared for gas chromatography-mass spectrometry analyses order identify quantify its metabolites homovanillic alcohol (HVA1c) acid (HVA). results indicate undergoes action catechol-O-methyl transferase (COMT), enzymes catecholamine catabolism, resulting an enhanced excretion HVA1c. also found a significant increase HVA, indicating oxidation ethanolic residue and/or HVA1c humans. both significantly correlated with dose administered HT.