PHARMACOLOGICAL PROPERTIES OF N‐(3′,4′‐DIMETHOXYCINNAMOYL) ANTHRANILIC ACID (N‐5′), A NEW ANTI‐ATOPIC AGENT

摘要: 1 N-(3'-4'-dimethoxycinnamoyl) anthranilic acid (N-5') exhibited a dose-dependent, potent inhibition of the passive cutaneous anaphylaxis (PCA) mediated by homocytotropic antibodies (HTA), which was hardly affected anti-inflammatory agents such as phenylbutazone, indomethacin and prednisolone at any dose used. The HTA-induced PCA significantly inhibited combined treatment with diphenydramine cyproheptadine. 2 Doses N-5' potently only slightly heterologous produced anti-bovine serum albumin (BSA) rabbit serum. This clearly prednisolone. Diphenydramine cyproheptadine, singly or slightly. 3 increased vascular permeability caused histamine 5-hydroxytryptamine diphenyldramine but not 4 150 mg/kg orally rat paw oedema induced carrageenin about 26% while significant inhibition. 5 concentrations 100 1000 muM (by 52% 95%, respectively) release from peritoneal cells HTA; 10 had little effect. Histamine phenylbutazone muM. Prednisolone no effect on 6 These findings suggest that may be due to is different actions