Plasma concentrations of risperidone and olanzapine during coadministration with oxcarbazepine.

摘要: Summary: Purpose: Oxcarbazepine (OZC) is a secondgeneration antiepileptic drug (AED) that also may be used as mood stabilizer. Unlike carbamazepine (CBZ), which an inducer of the cytochrome P-450 isoforms and accelerate elimination several therapeutic agents, OXC seems to have only modest inducing action. The aim this investigation was evaluate effect treatment with on plasma concentrations new antipsychotics risperidone olanzapine. Methods: OXC, at dosage 900‐1,200 mg/day, administered for 5 consecutive weeks 25 outpatients, 10 men 15 women, aged 64 years, bipolar or schizoaffective disorder. Twelve patients were stabilized therapy (2‐6 mg/day) 13 olanzapine (5‐20 mg/day). Steady-state its active metabolite 9-hydroxyrisperidone (9-OH-risperidone) measured by high-pressure liquid chromatography (HPLC) before addition after from start adjunctive treatment. Results: caused minimal no significant changes in mean levels (from 5.6 ± 3.6 ng/ml baseline 4.8 2.6 week 5), 9-OH-risperidone 23.6 7.5 24.7 7.4 ng/ml), 26.5 5.7 27.8 5.1 ng/ml). coadministration either well tolerated. Conclusions: Our findings indicate does not affect olanzapine, thus confirming weak hepatic drug-metabolizing enzymes. Ke yW ords: Oxcarbazepine—Risperidone— Olanzapine—Drug interaction.