Pharmacology of Methamphetamine

摘要: Methamphetamine increases dopamine levels in the central nervous system (CNS) by as much 2,600%, primarily stimulating presynaptic release of neurotransmitter, rather than re-uptake blockade [9, 11]. Such increase has effect regions brain linked with vigilance and action heart [11]. For a short while, user feels sharper, stronger more energetic. It is believed that significant proportion dopamine-producing cells can be damaged prolonged exposure to even low methamphetamine, this responsible for reduced dopamine; affect memory-, attention- decision-taking functions. Chronic methamphetamine abuse reported lead reduction grey matter brain, greater those dementia or schizophrenia patients, though needs further clarification. Associated health risks involve social family problems, including risky sexual behavior. Drug-induced psychosis may result. effects last days body, some degree neurological impairment up 2 years after cessation drug [12].