Nerve growth factor-mediated sexual differentiation of the rat hypothalamus.
作者： Masahiro Yanase , Akie Honmura , Takao Akaishi , Yasuo Sakuma
DOI: 10.1016/0168-0102(88)90021-1
关键词:
摘要: Injection of antibody to nerve growth factor into the cerebral lateral ventricle blocked testosterone-induced behavioral defeminization neonatal female rats. When tested as adults following ovariectomy and combined estrogen-progesterone treatment, injected animals showed a significantly higher lordosis quotient than testosterone-treated, normal rabbit serum-infused controls. Failure vaginal opening clitoral enlargement manifested well-documented masculinizing effect testosterone on genitalia in experimental well control animals. Estrogen sensitivity hypothalamic neurons which are responsible for induction was retained Recordings antidromic action potentials from ventromedial nucleus hypothalamus stimulation midbrain central gray revealed that estrogen decreased activation threshold shortened absolute refractory period efferents along with estrogen-induced In group, neuronal lost altogether activation.
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