Sun Exposure, Sunbeds and Sunscreens and Melanoma. What Are the Controversies?

摘要: The association between various measures of sun exposure and melanoma risk is quite complex to dissect as many case–control studies included different subtypes melanomas which are likely be biologically different, so interpretation the data difficult. Screening bias in countries with high levels also an issue. Now that progress being made genetic subclassification tumours, it apparent have somatic changes according body sites/histological UV may relevant for some but not all types melanomas. Melanoma behaviour points non-sun-related factors, gene–environment interactions likely. As only environmental factor ever linked melanoma, still prudent avoid excessive sunburn especially poor tanners. However, impact strict avoidance, should recommended, take years vitamin D deficiency a now common health issue Caucasian populations, significant on general.