Efficient pH Dependent Drug Delivery to Target Cancer Cells by Gold Nanoparticles Capped with Carboxymethyl Chitosan
作者： Alle Madhusudhan , Gangapuram Bhagavanth Reddy , Maragoni Venkatesham , Guttena Veerabhadram , Dudde Anil Kumar
DOI: 10.3390/IJMS15058216
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摘要: Doxorubicin (DOX) was immobilized on gold nanoparticles (AuNPs) capped with carboxymethyl chitosan (CMC) for effective delivery to cancer cells. The carboxylic group of interacts the amino doxorubicin forming stable, non-covalent interactions surface AuNPs. ionizes at acidic pH, thereby releasing drug effectively pH suitable target DOX loaded were absorbed by cervical cells compared free and their uptake further increased conditions induced nigericin, an ionophore that causes intracellular acidification. These results suggest AuNPs pH-triggered properties is a novel nanotheraputic approach overcome resistance in cancer.
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