GISCOME – Genetics of Ischaemic Stroke Functional Outcome network: A protocol for an international multicentre genetic association study

作者: Jane M Maguire , Steve Bevan , Tara M Stanne , Erik Lorenzen , Israel Fernandez-Cadenas

DOI: 10.1177/2396987317704547

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摘要: IntroductionGenome-wide association studies have identified several novel genetic loci associated with stroke risk, but how factors influence outcome is less studied. The Genetics of Ischaemic Stroke Functional network aims at performing outcome. We here describe the study protocol and methods basis outcome.MethodsThe has assembled patients from 12 ischaemic projects genome-wide genotypic data International Consortium National Institute Neurological Diseases Network initiatives. assessed availability baseline variables, metrics time-points for collection data.ResultsWe collected 8831 cases data. Modified Rankin score was metric most readily available. detected heterogeneity between coh...

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