Light-dependent cytotoxic reactions of anthracene.

摘要: — Anthracene is a photodynamic compound in vitro. In the presence of oxygen, it known to generate singlet oxygen and participate Type II reactions. aqueous solution, also participates I reactions, such as photoreduction cytochrome c, which can be suppressed by superoxide dismutase. argon, direct c takes place. induces hemolysis human erythrocytes inactivates Escherichia coli cells photodynamically. By using series E. strains differing DNA repair capabilities catalase proficiency, sensitivity inactivation anthracene plus NUV was correlated with deficiency rather than particular deficiencies. The fact that carotenoid genes cloned expressed offered partial protection suggests membrane may one possible target for NUV. inactivated Haemophilus influenzae transforming led nicking supercoiled pBR322 vivo, therefore, phototoxic molecule whose cytotoxicity could result damage more target.