Estradiol metabolism: an endocrine biomarker for modulation of human mammary carcinogenesis
作者： N T Telang , M Katdare , H L Bradlow , M P Osborne
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摘要: The natural estrogen 17beta-estradiol (E2) has a profound influence on proliferation and neoplastic transformation of mammary epithelium. role cellular metabolism E2 in carcinogenesis, however, remains to be elucidated. Explant culture cell models developed from noncancerous human tissue were used examine modulation response treatment with prototype rodent carcinogens the ability naturally occurring phytochemical indole-3-carbinol (13C) regulate aberrant proliferation. In two models, chemical 7,12-dimethylbenz[a]anthracene benzo[a]pyrene altered as determined radiometric (tritium release) gas chromatography-mass spectrometry (GC-MS) assays. This alteration was accompanied by abrogation apoptosis extent replicative DNA synthesis, S-phase fraction Sub G0 (apoptotic) peak. Exposure carcinogen-initiated cultures 13C resulted induction C2-hydroxylation downregulation hyperproliferation. Determination initiators modulators carcinogenesis evaluation cycle related markers for may provide mechanism-oriented approach validate an endocrine biomarker prevention carcinogenesis.
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jstor.org 参考文章(45)
Clifford W. Welsch, Rodent Models To Examine In Vivo Hormonal Regulation of Mammary Gland Tumorigenesis Springer, Boston, MA. pp. 163- 179 ,(1987) , 10.1007/978-1-4613-0943-7_10
Walter J. Esselman, Cori Oakley, Clifford W. Welsch, Yi-Fan Zhai, Michael N. Gould, Bingcheng Wang, Howard Beittenmiller, Increased Expression of Specific Protein Tyrosine Phosphatases in Human Breast Epithelial Cells Neoplastically Transformed by the neu Oncogene Cancer Research. ,vol. 53, pp. 2272- 2278 ,(1993)
William A. Tricomi, Cynthia J. Moore, Michael N. Gould, Interspecies Comparison of Polycyclic Aromatic Hydrocarbon Metabolism in Human and Rat Mammary Epithelial Cells Cancer Research. ,vol. 46, pp. 4946- 4952 ,(1986)
Johanna C. Seegers, Mona-Liza Lottering, Marianne Haag, Effects of 17β-Estradiol Metabolites on Cell Cycle Events in MCF-7 Cells Cancer Research. ,vol. 52, pp. 5926- 5932 ,(1992)
J Schneider, M M Huh, H L Bradlow, J Fishman, Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells. Journal of Biological Chemistry. ,vol. 259, pp. 4840- 4845 ,(1984) , 10.1016/S0021-9258(17)42922-X
H. LEON BRADLOW, DANIEL W. SEPKOVIC, NITIN T. TELANG, MICHAEL P. OSBORNE, Indole‐3‐carbinol Annals of the New York Academy of Sciences. ,vol. 768, pp. 180- 200 ,(1995) , 10.1111/J.1749-6632.1995.TB12121.X
Clifford W. Welsch, Host Factors Affecting the Growth of Carcinogen-induced Rat Mammary Carcinomas: A Review and Tribute to Charles Brenton Huggins Cancer Research. ,vol. 45, pp. 3415- 3443 ,(1985)
Malcolm C. Pike, Darcy V. Spicer, Laila Dahmoush, Michael F. Press, Estrogens, Progestogens, Normal Breast Cell Proliferation, and Breast Cancer Risk Epidemiologic Reviews. ,vol. 15, pp. 17- 35 ,(1993) , 10.1093/OXFORDJOURNALS.EPIREV.A036102
Toshihiro Kojima, Hideki Mori, Takuji Tanaka, Chemoprevention of Spontaneous Endometrial Cancer in Female Donryu Rats by Dietary Indole-3-carbinol Cancer Research. ,vol. 54, pp. 1446- 1449 ,(1994)
M. P. Osborne, H. L. Bradlow, G. Y. C. Wong, N. T. Telang, Upregulation of Estradiol C16α-hydroxylation in Human Breast Tissue: a Potential Biomarker of Breast Cancer Risk Journal of the National Cancer Institute. ,vol. 85, pp. 1917- 1920 ,(1993) , 10.1093/JNCI/85.23.1917