NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and lung cancer risk: a meta-analysis.
作者： Yuqing Lou , Rong Li , Liwen Xiong , Aiqin Gu , Chunlei Shi
DOI: 10.1007/S13277-013-0985-7
关键词:
摘要: No clear consensus has been reached on the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer risk. We performed a meta-analysis to summarize possible association. conducted computer retrieval of PubMed Embase databases prior May 2013. References retrieved articles were also screened. The fixed-effects model random-effects applied for dichotomous outcomes combine results individual studies. According inclusion criteria, 25 (32 studies) finally included. There was no statistical association between risk in overall, East Asians, African Americans, or Hispanics. In Caucasians, significant found allele comparison (T vs. C) (P = 0.04, OR 1.09, 95% CI 1.00–1.19, Pheterogeneity 0.24, model). subgroup squamous cell carcinoma, borderline significance could be dominant genetic (TT + CT CC) 0.05, 1.20, 1.00–1.43, 0.65, Significant 0.03, 1.21, 1.01–1.44, 0.68, small risk, 1.68, 95%CI 1.05–2.68, 0.10, model) homozygote 0.02, 2.79, 1.14–6.85, 0.72, observed adenocarcinoma subgroup. Our study suggested that NQO1 might associate with Caucasians. This carcinoma
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