SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer.
作者： Ahmed Ashour Ahmed , Zhen Lu , Nicholas B. Jennings , Dariush Etemadmoghadam , Luisa Capalbo
DOI: 10.1016/J.CCR.2010.06.018
关键词:
摘要: Regulators of mitosis have been successfully targeted to enhance response taxane chemotherapy. Here, we show that the salt inducible kinase 2 (SIK2) localizes at centrosome, plays a key role in initiation mitosis, and regulates localization centrosome linker protein, C-Nap1, through S2392 phosphorylation. Interference with known SIK2 inhibitor PKA induced SIK2-dependent splitting interphase while depletion blocked separation sensitizing ovarian cancers paclitaxel culture xenografts. Depletion also delayed G1/S transition reduced AKT Higher expression significantly correlated poor survival patients high-grade serous cancers. We believe these data identify as plausible target for therapy
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