Applications of the Keap1-Nrf2 system for gene and cell therapy.

摘要: Oxidative stress has been implicated to play a role in number of acute and chronic diseases including injuries the central nervous system, neurodegenerative cardiovascular diseases, cancer. The redox-activated transcription factor Nrf2 shown protect many different cell types organs from variety toxic insults, whereas cancers, unchecked activity increases expression cytoprotective genes and, consequently, provides growth advantage cancerous cells. Herein, we discuss current preclinical gene therapy approaches either increase or decrease with special reference neurological In addition, stem for disorders.