Preservation of kidneys by machine perfusion influences gene expression and may limit ischemia/reperfusion injury.
作者： Michal Wszola , Artur Kwiatkowski , Piotr Domagala , Agnieszka Wirkowska , Monika Bieniasz
DOI: 10.7182/PIT2014384
关键词:
摘要: Context—Machine perfusion improves graft survival. Histopathologic analysis reveals a lower incidence of chronic rejection and interstitial fibrosis in kidneys preserved with machine perfusion. Ischemic/reperfusion injury may help to explain these findings.Objective—To assess the activation genes correlated ischemic/reperfusion under different conditions before transplant.Design/Patients—Between 2005 2006, 69 kidney biopsy specimens were collected patients followed up for 5 years after that.Intervention—Before transplant, or cold storage. Donors from storage groups did not differ regard age, sex, hemodynamic status. Recipients divided into groups: expanded criteria donor-machine (n = 16), standard 10), donor-cold 9), 27); 7 retr...
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