Ginsenoside Rg1 Attenuates Cigarette Smoke-Induced Pulmonary Epithelial-Mesenchymal Transition via Inhibition of the TGF-β1/Smad Pathway.
作者： Sibin Guan , Weiguo Xu , Fengfeng Han , Wen Gu , Lin Song
DOI: 10.1155/2017/7171404
关键词:
摘要: Epithelial-mesenchymal transition (EMT) is a process associated with airway remodeling in chronic obstructive pulmonary disease (COPD), which leads to progressive destruction. Panax ginseng traditional herbal medicine that has been shown improve function and exercise capacity patients COPD. Ginsenoside Rg1 one of the main active components was inhibit oxidative stress inflammation. The present study investigated hypothesis ginsenoside attenuates EMT COPD rats induced by cigarette smoke (CS) human bronchial epithelial (HBE) cells exposed extract (CSE). Our data showed CS or CSE exposure increased expression mesenchymal marker α-smooth muscle actin (α-SMA) decreased cadherin (E-cad) both lung tissues HBE cells, markedly suppressed Rg1. Importantly, CS-induced upregulation TGF-β1/Smad pathway components, including TGF-β1, TGF-βR1, phospho-Smad2, phospho-Smad3, also inhibited Additionally, mimicked effect SB525334, TGF-βR1-Smad2/3 inhibitor, on suppression CSE-induced cells. Collectively, we concluded alleviates EMT, via inhibition pathway.
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core.ac.uk 参考文章(48)
Suhong Bao, Yun Zou, Bing Wang, Yinjiao Li, Jiali Zhu, Yan Luo, Jinbao Li, Ginsenoside Rg1 improves lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and modulating infiltration of M2 macrophages. International Immunopharmacology. ,vol. 28, pp. 429- 434 ,(2015) , 10.1016/J.INTIMP.2015.06.022
Cuong Thach Nguyen, Truc Thanh Luong, Seung Yeop Lee, Gyu Lee Kim, Hyogyoung Kwon, Hong-Gyun Lee, Chae-Kyu Park, Dong-Kwon Rhee, None, Panax ginseng aqueous extract prevents pneumococcal sepsis in vivo by potentiating cell survival and diminishing inflammation. Phytomedicine. ,vol. 22, pp. 1055- 1061 ,(2015) , 10.1016/J.PHYMED.2015.07.005
A Janoff, H Carp, Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro. The American review of respiratory disease. ,vol. 116, pp. 65- 72 ,(1977) , 10.1164/ARRD.1977.116.1.65
Malik Mahmood, Sukhwinder Singh Sohal, Shakti Dhar Shukla, Ashutosh Hardikar, Wan Danial Noor, Hans Konrad Muller, Darryl Knight, Eugene Haydn Walters, Chris Ward, Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction International Journal of Chronic Obstructive Pulmonary Disease. ,vol. 10, pp. 1515- 1524 ,(2015) , 10.2147/COPD.S81032
Hidenori Kasai, Jeremy T Allen, Roger M Mason, Takashi Kamimura, Zhi Zhang, TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT) Respiratory Research. ,vol. 6, pp. 56- 56 ,(2005) , 10.1186/1465-9921-6-56
Dong Sun, Bing Wang, Ming Shi, Yun-Xia Zhang, Lin-Fu Zhou, Zhi-Rong Liu, Zhong-Liang Wu, Wen Jiang, Jun-Liang Han, Li-Ze Xiong, Gang Zhao, Pharmacokinetic, tissue distribution and excretion of ginsenoside-Rd in rodents. Phytomedicine. ,vol. 19, pp. 369- 373 ,(2012) , 10.1016/J.PHYMED.2011.08.061
Bao-Ying Hu, Xian-Jin Liu, Ren Qiang, Zheng-Lin Jiang, Li-Hua Xu, Guo-Hua Wang, Xia Li, Bin Peng, Treatment with ginseng total saponins improves the neurorestoration of rat after traumatic brain injury. Journal of Ethnopharmacology. ,vol. 155, pp. 1243- 1255 ,(2014) , 10.1016/J.JEP.2014.07.009
Shao-Lai Zhou, Zheng-Jun Zhou, Zhi-Qiang Hu, Xun Li, Xiao-Wu Huang, Zheng Wang, Jia Fan, Zhi Dai, Jian Zhou, CXCR2/CXCL5 axis contributes to epithelial-mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling. Cancer Letters. ,vol. 358, pp. 124- 135 ,(2015) , 10.1016/J.CANLET.2014.11.044
Wen Gu, Lin Song, Xiao-Ming Li, Di Wang, Xue-Jun Guo, Wei-Guo Xu, Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways Scientific Reports. ,vol. 5, pp. 8733- 8733 ,(2015) , 10.1038/SREP08733
Lijuan Pang, Qiuxiang Li, Cuilei Wei, Hong Zou, Shugang Li, Weiwei Cao, Jianwei He, Yang Zhou, Xinxin Ju, Jiaojiao Lan, Yutao Wei, Chengyan Wang, Wei Zhao, Jianming Hu, Wei Jia, Yan Qi, Fudong Liu, Jinfang Jiang, Li Li, Jin Zhao, Weihua Liang, Jianxin Xie, Feng Li, TGF-β1/Smad Signaling Pathway Regulates Epithelial-to-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma: In Vitro and Clinical Analyses of Cell Lines and Nomadic Kazakh Patients from Northwest Xinjiang, China PLoS ONE. ,vol. 9, pp. e112300- ,(2014) , 10.1371/JOURNAL.PONE.0112300