Acrolein: a respiratory toxin that suppresses pulmonary host defense

摘要: Acrolein is a ubiquitous environmental pollutant that known to cause respiratory tract injury and suppression of pulmonary host defense against infections in animal models. The mechanisms acrolein-induced are not well understood. It has been generally believed epithelial responsible for the acrolein-caused decrease resistance infection. Emerging evidence suggests, however, alveolar macrophage also key target defense. likely combination cell inhibition function may be To better assess health risk exposure levels acrolein, more population-based studies needed monitor acrolein adverse effects associated with such exposures.