Radiosurgery/stereotactic radiotherapy in combination with immunotherapy and targeted agents for melanoma brain metastases.
作者： Elisabetta Trino , Cristina Mantovani , Serena Badellino , Umberto Ricardi , Andrea Riccardo Filippi
DOI: 10.1080/14737140.2017.1296764
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摘要: ABSTRACTIntroduction: The clinical landscape of advanced melanoma drastically changed after the introduction both targeted therapies and immunotherapy. This rapid development in systemic led to a change management patients with brain metastases, subsequent need re-assess role local therapies, particular stereotactic radiosurgery (SRS).Areas covered: In this non-systematic review, we report on current knowledge use SRS combination immunotherapy BRAF/MEK inhibitors for as well ongoing trials field.Expert commentary: It is now more common observe metastases better performance status prolonged life expectancy. A therapy immunotherapy, different sequences, has been shown be feasible tolerable, basis retrospective reports. Additional data from prospective are however needed confir...
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