A Novel Strategy to Improve the Therapeutic Efficacy of Gemcitabine for Non-Small Cell Lung Cancer by the Tumor-Penetrating Peptide iRGD
作者： Qing Zhang , Yang Zhang , Ke Li , Haiyu Wang , Huizhong Li
DOI: 10.1371/JOURNAL.PONE.0129865
关键词:
摘要: Non-small cell lung cancer (NSCLC) is the most common type of cancer, comprising approximately 75–80% all cancers. Gemcitabine an approved chemotherapy drug for NSCLC. The objective this study was to develop a novel strategy improve therapeutic efficacy NSCLC by co-administered iRGD peptide. We showed that rates positive expression αvβ3, αvβ5 and NRP-1 in A549 line were 68.5%, 35.3% 94.5%, respectively. amount Evans Blue accumulated tumor Blue+iRGD group 2.5 times group. growth inhibition tumors group, Gemcitabine+iRGD 8%, 59.8% 86.9%, results mechanism studies PCNA decreased 71.5% compared with rate apoptosis 2.2 time Therefore, tumor-penetrating Peptide can enhance ability xenograft. combined application may be clinical patients
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