Drug utilization, safety and clinical use of Actos and Avandia.

摘要: AND OBJECTIVE: The impetus for this review was recent increased warnings of cardiovascular toxicity, fractures and bladder cancer associated with glitazone use. METHODS: A drug utilization performed regarding the use Actos (pioglitazone) Avandia (rosiglitazone) at Cooper Green Mercy Hospital (CGMH), an inner city safety net hospital in Birmingham, Alabama. Pharmacy records were reviewed hospital-wide to determine usage patterns all anti-diabetic medications. Medline FDA websites searched articles on efficacy pioglitazone rosiglitazone. Considerations relative profile, comparative efficacy, indications, cost, profile two available medications class. RESULTS: On basis these factors, a switch rosiglitazone prescriptions implemented, which estimated result savings $83,000 first year. No episodes worsening control diabetes anticipated, nor decreased or adverse effects as automatically switching patients from time prescription filling. CONCLUSIONS: conclusions can be summarized number key points.