In vitro models of inhalation toxicity and disease. The report of a FRAME workshop.

摘要: The aim of research in the FRAME Alternatives Laboratory at University Nottingham Medical School is summarised, i.e. to use human cell culture-based projects and vivo studies volunteers as alternatives rodent models study disease. This especially important when available animal do not adequately represent pathophysiological situation humans. approach exemplified by summaries on effects starvation skeletal muscle volunteers, lipid metabolism obese female volunteers.