Fischer and Lewis rat strains show differential cocaine effects in conditioned place preference and behavioral sensitization but not in locomotor activity or conditioned taste aversion.

摘要: Current research suggests there are genetic differences in susceptibility to drug abuse. One way examine this relationship is study inbred strains, such as Lewis (LEW) and Fischer 344 (F344) rats, that show differential biochemical behavioral effects response psychoactive drugs. In the present several of cocaine were compared these including conditioned place preference (CPP), taste aversion locomotor activity. Cocaine CPP was greater LEW rats than F344 rats. contrast, did not differ between or activity levels seen after first administration. however, showed enhanced repeated administrations at all doses tested, an effect These data suggest development due detection inability condition cocaine. Rather, may reflect strain be related previously observed two rat strains.