Microvessels Density in Uterine Leiomyosarcoma

摘要: Uterine leiomyosarcomas (LMS) are rare tumors typically presenting rapid growth and unfavorable outcome. Nowadays the results of uterine LMS treatment do not meet expectations. Angiogenesis is one processes investigated to be target for future treatment. The aim research was assess microvessels density (MVD) in tumor samples collected from 50 patients with histological confirmed leiomyosarcoma investigate statistical relations between MVD, survival, FIGO stage tumor. assessment carried out using immunohistochemistry methods anti-CD34 antibody. No significant difference MVD stages observed. Furthermore, contrary many other malignancies, we found no relation overall 2-year survival. Results obtained study suggest that on vascular mimicry mesenchymal epithelial transition (MET) may play important role development LMS. survival leads conclusion only angiogenesis but mechanisms as well should taken into consideration planning research.