Haemostatic profiles assessed by thromboelastography in patients with end-stage renal disease.

摘要: Summary Patients with end-stage renal disease (ESRD) have abnormalities in the cellular and plasmatic systems regulating blood homeostasis, which may contribute to their risk for thrombotic bleeding complications. However, relative contributions this population are poorly understood. The aim of study was evaluate distribution enzymatic ESRD patients on haemodialysis as assessed by thromboelastography (TEG®). Whole samples were analysed TEG (n=70) a control group subjects coronary artery disease. Profiles constructed considering maximum amplitude (MA), marker platelet function, reaction time (R), thrombin generation, values. R values higher compared (8.2 ± 2.8 vs. 5.7 1.9 minutes [min], p <0.0001), while there no differences MA (66.7 8.1 66.2 6.6 mm, p=0.562). Normal manufacturer defined coagulation (2–8 min) aggregation (51–69 mm) parameters present 31% 56% controls (p=0.006). A hypocoagulable status observed 42.9% 8.9% (p<0.0001). There showed hyperaggregable 41.4% versus 35.7% cases (p=0.603). Abnormalities both 15.7% 1.4% (p= 0.004), more common among older 0.005). In conclusion, an elevated prevalence abnormal haemostatic profiles,