De novo appearance of der(1;7)(q10;p10) is associated with leukemic transformation and unfavorable prognosis in essential thrombocythemia
作者： Hui-Hua Hsiao , Yoshikazu Ito , Goro Sashida , Junko H. Ohyashiki , Kazuma Ohyashiki
DOI: 10.1016/J.LEUKRES.2005.03.011
关键词:
摘要: Leukemic transformation or myelofibrosis is a major concern in managing patients with chronic myeloproliferative disorders, including essential thrombocythemia (ET). We analyze the relationship between cytogenetic changes and 89 ET; 8 experienced transformation, 2 acute leukemia following myelofibrosis, 3 leukemia, myelofibrosis. Among eight showing two developing derived from group normal cytogenetics, but remaining six were categorized as de novo appearance of changes. Two had at time diagnosis, whereas showed der(1;7) during their period. Moreover, did not receive any cytotoxic agents before der(1;7), indicating that detection may have predictive value for only leukemic also unfavorable prognosis.
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Jacques M.J.C. Scheres, Theo W.J. Hustinx, Joep P.M. Geraedts, C.Henk W. Leeksma, Paul S. Meltzer, Translocation 1; 7 in hematologic disorders: a brief review of 22 cases Cancer Genetics and Cytogenetics. ,vol. 18, pp. 207- 213 ,(1985) , 10.1016/0165-4608(85)90085-8
Claire N. Harrison, Current trends in essential thrombocythaemia British Journal of Haematology. ,vol. 117, pp. 796- 808 ,(2002) , 10.1046/J.1365-2141.2002.03474.X
Ciril Rozman, Evarist Feliu, Manuel Giralt, Daniel Rubio, María-Teresa Cortés, Life expectancy of patients with chronic nonleukemic myeloproliferative disorders. Cancer. ,vol. 67, pp. 2658- 2663 ,(1991) , 10.1002/1097-0142(19910515)67:10<2658::AID-CNCR2820671042>3.0.CO;2-C
G. Finazzi, T. Barbui, Treatment of essential thrombocythemia with special emphasis on leukemogenic risk. Annals of Hematology. ,vol. 78, pp. 389- 392 ,(1999) , 10.1007/S002770050536
M. L. Randi, F. Fabris, A. Girolami, Second malignancies in patients with essential thrombocythaemia. British Journal of Haematology. ,vol. 116, pp. 923- 923 ,(2002) , 10.1111/J.1365-2141.2002.3346_1.X
Juergen Thiele, Hans Michael Kvasnicka, Annette Schmitt-Graeff, Rudolph Zankovich, Volker Diehl, Follow-up examinations including sequential bone marrow biopsies in essential thrombocythemia (ET): a retrospective clinicopathological study of 120 patients. American Journal of Hematology. ,vol. 70, pp. 283- 291 ,(2002) , 10.1002/AJH.10116
Guido Finazzi, Marco Ruggeri, Francesco Rodeghiero, Tiziano Barbui, Second malignancies in patients with essential thrombocythaemia treated with busulphan and hydroxyurea: long-term follow-up of a randomized clinical trial. British Journal of Haematology. ,vol. 110, pp. 577- 583 ,(2000) , 10.1046/J.1365-2141.2000.02188.X
Akira Hattori, Reizo Nagayama, Kenji Kishi, Ichiro Fuse, Masaharu Hanano, Shin-Ichiro Takizawa, Tomio Takeshige, Akira Shibata, Primary Thrombocythemia in Japan: A Survey of 225 Patients. Leukemia & Lymphoma. ,vol. 4, pp. 177- 186 ,(1991) , 10.3109/10428199109068063
P. O. Andersson, B. Ridell, H. Wadenvik, J. Kutti, Leukemic transformation of essential thrombocythemia without previous cytoreductive treatment Annals of Hematology. ,vol. 79, pp. 40- 42 ,(2000) , 10.1007/S002770050007
A. Tefferi, S. Murphy, Current opinion in essential thrombocythemia: pathogenesis, diagnosis, and management. Blood Reviews. ,vol. 15, pp. 121- 131 ,(2001) , 10.1054/BLRE.2001.0158