Why is the dog an ideal model for aging research

摘要: With many caveats to the traditional vertebrate species pertaining biogerontology investigations, it has been suggested that a most informative model is one which: 1) examines closely related species, or various members of same with naturally occurring lifespan variation, 2) already adequate medical procedures developed, 3) well annotated genome, 4) does not require artificial housing, and can live in its natural environment while being investigated, 5) allows considerable information be gathered within relatively short period time. The domestic dog unsurprisingly fits each criterion mentioned. become key system which evaluate surgical techniques novel medications because remarkable similarity between human canine conditions, treatments, response therapy. serves as disease for study, obviating need construct genetically modified examples disease. Just offers conditions diseases, simple observation leads conclusion aging phenotype also mimics human. Genotype information, biochemical GH/IGF-1 pathway, some limited longitudinal investigations have begun establishment aging. Although we find dogs indeed are study there independent pieces data, more "open" areas, ripe investigation.