Is statin-induced diabetes clinically relevant? A comprehensive review of the literature

摘要: In those predisposed to the development of diabetes (the insulin resistant, obese and older patients) statins may increase risk developing diabetes. Despite fact that conversion is generated from post hoc analyses, it seems be a class effect with dose-response relationship. However, have not been clearly shown diabetic microvascular complications (retinopathy, nephropathy neuropathy). Thus, clinical significance increased glucose levels in patients treated on uncertain. While exact mechanism for how unknown, possible explanation through reduction adiponectin levels. higher statin doses are more likely lead new-onset diabetes, every case caused, there approximately three cardiovascular events reduced high dose versus moderate therapy. Overall, small type 2 therapy far outweighed by potential decrease cardiac events.