Europe-Wide Meta-Analysis of Borrelia burgdorferi Sensu Lato Prevalence in Questing Ixodes ricinus Ticks.

摘要: Lyme borreliosis is the most common zoonotic disease transmitted by ticks in Europe and North America. Despite having multiple tick vectors, causative agent Borrelia burgdorferi sensu lato, vectored mainly Ixodes ricinus Europe. In present study, we aimed to review summarize existing data published from 2010 2016 concerning prevalence of B. s.l. spirochetes questing I. . The primary focus was evaluate infection rate these bacteria ticks, accounting for stage, adult gender, region detection method, as well investigate any changes over time. obtained compared findings a previous meta-study. literature search identified 24 countries with 115,028 total inspected We showed that significantly higher adults than nymphs females males. found significant differences between European regions, highest rates Central genospecies were afzelii garinii , despite negative correlation their rates. There no statistically among determined conventional polymerase chain reaction (PCR), nested PCR or real-time PCR. IMPORTANCE lato pathogenic bacterium whose clinical manifestations are associated borreliosis. This vector-borne major public health concern America may lead severe arthritic, cardiovascular neurological complications if left untreated. Although pathogen considered an important predictor risk, solitary isolated have only limited value. Here, provide summarized information about host-seeking its principal vector compare new results previously order changing trends infection.