Experimental and finite element analysis of the rat ulnar loading model—correlations between strain and bone formation following fatigue loading

摘要: The rat forelimb compression model has been used widely to study bone response mechanical loading. We strain gages assess load sharing between the ulna and radius in of adult Fisher rats. histology peripheral quantitative computed tomography (pQCT) quantify ulnar formation 12 days after vivo fatigue Lastly, we developed a finite element predict pattern surface strains during compression. Our findings indicate that at mid-shaft carries 65% applied compressive force on forelimb. observed large variations fatigue-induced over circumference length ulna. Bone was greatest 1-2 mm distal mid-shaft. At mid-shaft, woven medially. Finite analysis indicated consistent with compression-bending loading mode, occurring medial lesser tensile laterally. A peak -5190 microepsilon (for 13.3N compression) occurred longitudinal direction highly correlated predicted axial seven cross-sections (r2 = 0.89, p 0.014). in-plane poorly magnitude 51 periosteal locations 0.21, < 0.001), because least where were highest. These is regions high strain.