Identification of 24,25,26,27-tetranor-23-hydroxyvitamin D3 as a product of the renal metabolism of 24,25-dihydroxyvitamin D3
作者： Glenville Jones , Kenichi Kano , Sachiko Yamada , Takahiro Furusawa , Hiroaki Takayama
DOI: 10.1021/BI00311A028
关键词:
摘要: By cochromatography, mass spectrometry, and chemical derivatization, we have shown that a metabolite isolated from the perfused rat kidney incubated with 24-(R),25-dihydroxyvitamin D3 is indistinguishable chemically synthesized 24,25,26,27-tetranor-23-hydroxyvitamin D3. The new also produced 24-oxo-25-hydroxyvitamin but not 23(S),25-dihydroxyvitamin Enzymes required for synthesis of are absent in vitamin D deplete animal induced along 25-hydroxyvitamin-D3 24-hydroxylase by repletion. pathway 24,25-dihydroxyvitamin metabolism stimulated pre-treatment large doses D3, suggesting degradative one.
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