Mechanisms and Factors That Drive Extensive Human Immunodeficiency Virus Type-1 Hypervariability: An Overview.
作者： Mahmoud Mohammad Yaseen , Nizar Mohammad Abuharfeil , Mohammad Ali Alqudah , Mohammad Mahmoud Yaseen
关键词:
摘要: The extensive hypervariability of human immunodeficiency virus type-1 (HIV-1) populations represents a major barrier against the success currently available antiretroviral therapy. Moreover, it is still most important obstacle that faces development an effective preventive vaccine this infectious virus. Indeed, several factors can drive such within and between HIV-1 patients. These include: first, very low fidelity nature reverse transcriptase; second, extremely high replication rate; third, genomic recombination rate has. All these together with APOBEC3 proteins family immune antiviral drugs pressures populations. Studying mechanisms will provide valuable insights may guide therapeutic strategies infection in near future. To end, review, we summarized recent advances area research.
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