Carbene Complexes in Organic Synthesis [New Synthetic Methods (47)]

摘要: Transition metals are finding increasing use in organic synthesis on the borderline between “organic” and “inorganic” chemistry. Advantage is taken thereby of fact that metal-induced CC bond formation often takes place with remarkable selectivity. The rapid development has this area chemistry clearly demonstrated by carbene complexes, examples which now known for almost all transition elements, have transformed from organometallic curiosities into synthetically useful reagents less than two decades since first studies E. O. Fischer. They not only suitable as carbene-transfer agents but also undergo interesting cycloadditions other ligands co-ligand sphere. Their manipulation requires techniques no more complicated those Grignard reactions. Thus, complexes can be used natural products such vitamins or antibiotics.