Crystal-induced arthropathies: recent investigative advances

摘要: PURPOSE OF REVIEW To highlight recent investigations that have stimulated renewed interest in crystal-induced arthropathies. RECENT FINDINGS Specific diet-related and alcohol-related risks for gout been clarified, alternative urate-lowering treatments likely to benefit patients with difficult-to-treat are development. Progress toward understanding mechanisms underlying the renal deficits defining most cases of includes characterization a urate-specific tubule transporter explaining many aspects uric acid handling identification mutations UMOD gene, resulting altered uromodulin protein gout-associated disorders familial juvenile hyperuricemic nephropathy medullary cystic kidney disease type 2. A genetic marker associated risk severe allopurinol toxicity has reported. Hyperuricemia increasing incidence, as is complicated gout, especially among elderly cardiovascular comorbidities, organ transplants, or complex concomitant medication regimens. Asymptomatic hyperuricemia clearly hypertension, chronic disease, insulin resistance syndrome, pathogenetic significance these associations under intensive study. Mutation ANKH gene found some sporadic well calcium pyrophosphate deposition disease. SUMMARY The results clinical, epidemiologic, experimental, therapeutic presage advances management