Intravaginal ring for the delivery of unique combinations of antimicrobial compositions

摘要: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, well water-soluble metal salts and specified antiretroviral agents comprising NNRTIs NRTIs. Also disclosed methods making using the compositions. intravaginal rings delivering compounds, preferably high molecular weight polymers at essentially zero order rate. The include an outer layer non-water-swellable elastomer, polymer inner polymer, which is imbedded in layer, aperture through release thereof only aperture.