Octapeptide analogs of somatostatin having threonine at the sixth position
作者： William A. Murphy , David H. Coy
DOI:
关键词:
摘要: A compound of formula (I), wherein each A1 and A2, independently, is H C1-12 alkyl, C7-10 phenylalkyl, R1CO (where R1 C1-20 C3-20 alkenyl, phenyl, naphthyl, or phenylalkyl), R2OCO R C1-10 alkyl provided that when one A2 R2OCO, the other must be H; X1 X2, indepently, H, F, Cl, Br, OH, CH3, CF3, at least X2 A3 Phe Tyr; A4 NH2, NH-R3 (wherein R3 a saturated aliphatic C1-8 alkyl): pharmaceutically acceptable salt thereof; therapeutic composition comprising such compound; method using compound.
lens.org 参考文章(10)
William B. Arbuckle, Treatment of suspended solids--and adsorbable contaminant--containing liquid ,(1980)
Peter W. Ramwell, Pierre Braquet, Method for inhibiting blood vessel blockage using octapeptide compositions ,(1989)
Janos Pless, Wilfried Bauer, N-Acyl-polypeptides and processes for the production thereof ,(1982)
Andrew V. Schally, Ren Zhi Cai, Biologically active lysine containing octapeptides ,(1986)
Andrew V. Schally, Ren Z. Cai, Biologically active octapeptides ,(1985)
Dimitrios Sarantakis, Octapeptides lowering growth hormone ,(1980)
Victor J. Hruby, John T. Pelton, Cyclic polypeptides having mu-receptor specificity ,(1984)
David H. Coy, William A. Murphy, Mark L. Heiman, Therapeutic Somatostatin analogues ,(1988)
John T. Pelton, Wieslaw Kazmierski, Karoly Gulya, Henry I. Yamamura, Victor J. Hruby, Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors Journal of Medicinal Chemistry. ,vol. 29, pp. 2370- 2375 ,(1986) , 10.1021/JM00161A037
Janos Dr. Pless, Wilfried Bauer, Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use ,(1980)