Comparative analyses of chromatin landscape in white adipose tissue suggest humans may have less beigeing potential than other primates

摘要: Abstract Humans carry a much larger percentage of body fat than other primates. Despite the central role adipose tissue in metabolism, little is known about evolution white Phenotypic divergence often caused by genetic cis-regulatory regions. We examined landscape during human origins performing comparative analyses chromatin accessibility and chimpanzee using macaque as an outgroup. find that many regions are specifically closed humans under positive selection, located near genes involved with lipid contain short sequence motif beigeing fat, process which adipocytes transdifferentiated into beige adipocytes. While primary to store lipids, thermogeneic. The collective closing putative regulatory associated beiging suggests adaptive mechanism increases humans.