Synthesis of phosphonates and oligodeoxyribonucleotides derived from 2'-deoxyisoguanosine and 2'-deoxy-2-haloadenosines
作者： Frank Seela , Ralf Mertens , Zygmunt Kazimierczuk
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摘要: Oligonucleotides containing 2′-deoxyisoguanosine (1) or 2-chloro-2′-deoxyadenosine (2a) have been prepared by solid-phase synthesis. Suitably protected phosphonates 3a, 4a, and 4b as well the phosphoramidite of 1 obtained from nucleosides 1, 2a, 2bvia (dimethylamino)methylidene derivatives 5–7. 4,4′-Dimethoxytrityl groups were introduced to yield base-protected 8–10. Alternatively direct incorporation into oligonucleotides, they also photochemical conversion a 2a residue within oligonucleotide chain.
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