Inhibition of H3K27me3-Specific Histone Demethylases JMJD3 and UTX Blocks Reactivation of Herpes Simplex Virus 1 in Trigeminal Ganglion Neurons
作者： Harald G. P. Messer , Derek Jacobs , Adit Dhummakupt , David C. Bloom
DOI: 10.1128/JVI.03052-14
关键词:
摘要: ABSTRACT Herpes simplex virus 1 (HSV-1) genomes are associated with the repressive heterochromatic marks H3K9me2/me3 and H3K27me3 during latency. Previous studies have demonstrated that inhibitors of histone demethylases reduce ability HSV-1 to reactivate from Here we demonstrate GSK-J4, a specific inhibitor UTX JMJD3, inhibits reactivation sensory neurons in vitro . These results indicate removal mark plays key role reactivation.
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