Heterogeneity of intestinal lactase activity in children: relationship to lactase-phlorizin hydrolase messenger RNA abundance.
作者： Ward A Olsen , B U K Li , Mark Lloyd , Helen Korsmo
DOI: 10.1203/00006450-199605000-00023
关键词:
摘要: Despite extensive study in both humans and nonhuman mammals the mechanisms which regulate intestinal lactase activity, particularly during development, are incompletely understood. Our previous studies of human adults consistent with an important role lactase-phlorizin hydrolase (LPH) mRNA abundance determining persistence/nonpersistence phenotypes. intent present was to determine LPH regulation children. We therefore studied duodenal mucosal biopsies from 39 children undergoing diagnostic upper endoscopy whom significant small nutritional disease excluded. found no relationship between level enzymatic activity. observations suggest importance posttranscriptional
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