Overexpression of Agrt leads to obesity in transgenic mice.

作者: Melissa Graham , John R. Shutter , Ulla Sarmiento , lldiko Sarosi , Kevin L Stark

DOI: 10.1038/NG1197-273

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参考文章(10)
P Ray, K M Higgins, J C Tan, T Y Chu, N S Yee, H Nguyen, E Lacy, P Besmer, Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors. Genes & Development. ,vol. 5, pp. 2265- 2273 ,(1991) , 10.1101/GAD.5.12A.2265
Dennis Huszar, Catherine A Lynch, Victoria Fairchild-Huntress, Judy H Dunmore, Qing Fang, Lucy R Berkemeier, Wei Gu, Robert A Kesterson, Bruce A Boston, Roger D Cone, Francoise J Smith, L.Arthur Campfield, Paul Burn, Frank Lee, Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell. ,vol. 88, pp. 131- 141 ,(1997) , 10.1016/S0092-8674(00)81865-6
R. P. Woychik, M. L. Klebig, J. E. Wilkinson, J. G. Geisler, Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 4728- 4732 ,(1995) , 10.1073/PNAS.92.11.4728
Tung Ming Fong, Cheri Mao, Tanya MacNeil, Rubana Kalyani, Tim Smith, David Weinberg, Michael R. Tota, Lex H.T. Van der Ploeg, ART (Protein Product of Agouti-Related Transcript) as an Antagonist of MC-3 and MC-4 Receptors Biochemical and Biophysical Research Communications. ,vol. 237, pp. 629- 631 ,(1997) , 10.1006/BBRC.1997.7200
Jeffrey M. Friedman, The alphabet of weight control Nature. ,vol. 385, pp. 119- 120 ,(1997) , 10.1038/385119A0
Wei Fan, Bruce A. Boston, Robert A. Kesterson, Victor J. Hruby, Roger D. Cone, Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature. ,vol. 385, pp. 165- 168 ,(1997) , 10.1038/385165A0
Dongsi Lu, Derril Willard, Indravadan R. Patel, Sue Kadwell, Laurie Overton, Tom Kost, Michael Luther, Wenbiao Chen, Richard P. Woychik, William O. Wilkison, Roger D. Cone, Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature. ,vol. 371, pp. 799- 802 ,(1994) , 10.1038/371799A0
Scott J. Bultman, Edward J. Michaud, Richard P. Woychik, Molecular characterization of the mouse agouti locus Cell. ,vol. 71, pp. 1195- 1204 ,(1992) , 10.1016/S0092-8674(05)80067-4
J R Shutter, M Graham, A C Kinsey, S Scully, R Luthy, K L Stark, Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes & Development. ,vol. 11, pp. 593- 602 ,(1997) , 10.1101/GAD.11.5.593
A. Warbritton, A. M. Gill, T. T. Yen, T. Bucci, G. L. Wolff, Pancreatic islet cells in preobese yellow Avy/- mice: relation to adult hyperinsulinemia and obesity. Experimental Biology and Medicine. ,vol. 206, pp. 145- 151 ,(1994) , 10.3181/00379727-206-43733