Novel Mitochondria-Targeted Furocoumarin Derivatives as Possible Anti-Cancer Agents.

作者: Andrea Mattarei , Matteo Romio , Antonella Managò , Mario Zoratti , Cristina Paradisi

DOI: 10.3389/FONC.2018.00122

关键词:

摘要: … , ie, by producing a “targeting pro-drug.” Mitochondria are a … system and the triphenylphosphonium (TPP) lipophilic cation. … a prodrug in which the coumarinic moiety and the …

参考文章(63)
Marco Sciacovelli, Edoardo Gaude, Mika Hilvo, Christian Frezza, The Metabolic Alterations of Cancer Cells Methods in Enzymology. ,vol. 542, pp. 1- 23 ,(2014) , 10.1016/B978-0-12-416618-9.00001-7
Bence Sipos, Simone Möser, Holger Kalthoff, Virag Török, Matthias Löhr, Günter Klöppel, A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. Virchows Archiv. ,vol. 442, pp. 444- 452 ,(2003) , 10.1007/S00428-003-0784-4
Hendrik Ungefroren, Doris Henne-Bruns, Holger Kalthoff, Bernd Kremer, Martina Voss, Christian Roeder, Martina Jansen, Human Pancreatic Adenocarcinomas Express Fas and Fas Ligand Yet Are Resistant to Fas-mediated Apoptosis Cancer Research. ,vol. 58, pp. 1741- 1749 ,(1998)
Eun Mi Kim, Jong Kuk Park, Sang-Gu Hwang, Wun-Jae Kim, Zheng-Gang Liu, Sang Won Kang, Hong-Duck Um, Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins Oncotarget. ,vol. 5, pp. 8452- 8465 ,(2014) , 10.18632/ONCOTARGET.2320
Yeon Ju Yang, Jin Young Baek, Jail Goo, Yoonho Shin, Jong Kuk Park, Ji Yong Jang, Su Bin Wang, Woojin Jeong, Hwa Jeong Lee, Hong-Duck Um, Sang Kook Lee, Yongseok Choi, Sue Goo Rhee, Tong-Shin Chang, None, Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I Antioxidants & Redox Signaling. ,vol. 24, pp. 453- 469 ,(2016) , 10.1089/ARS.2014.6187
L Leanza, L Trentin, K A Becker, F Frezzato, M Zoratti, G Semenzato, E Gulbins, I Szabo, Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia. Leukemia. ,vol. 27, pp. 1782- 1785 ,(2013) , 10.1038/LEU.2013.56
Ni Liu, Toru Furukawa, Masao Kobari, Ming-Sound Tsao, Comparative Phenotypic Studies of Duct Epithelial Cell Lines Derived from Normal Human Pancreas and Pancreatic Carcinoma The American Journal of Pathology. ,vol. 153, pp. 263- 269 ,(1998) , 10.1016/S0002-9440(10)65567-8
Lan-Feng Dong, Victoria J. A. Jameson, David Tilly, Jiri Cerny, Elahe Mahdavian, Alvaro Marín-Hernández, Luz Hernández-Esquivel, Sara Rodríguez-Enríquez, Jan Stursa, Paul K. Witting, Bela Stantic, Jakub Rohlena, Jaroslav Truksa, Katarina Kluckova, Jeffrey C. Dyason, Miroslav Ledvina, Brian A. Salvatore, Rafael Moreno-Sánchez, Mark J. Coster, Stephen J. Ralph, Robin A. J. Smith, Jiri Neuzil, Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II Journal of Biological Chemistry. ,vol. 286, pp. 3717- 3728 ,(2011) , 10.1074/JBC.M110.186643
Lubomir Prochazka, Stepan Koudelka, Lan-Feng Dong, Jan Stursa, Jacob Goodwin, Jiri Neca, Josef Slavik, Miroslav Ciganek, Josef Masek, Katarina Kluckova, Maria Nguyen, Jaroslav Turanek, Jiri Neuzil, Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to α-tocopheryl succinate. Apoptosis. ,vol. 18, pp. 286- 299 ,(2013) , 10.1007/S10495-012-0795-1
Hong Ouyang, Lun-jun Mou, Catherine Luk, Ni Liu, Jana Karaskova, Jeremy Squire, Ming-Sound Tsao, Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype American Journal of Pathology. ,vol. 157, pp. 1623- 1631 ,(2000) , 10.1016/S0002-9440(10)64800-6