Association between refractive error and the intrinsically photosensitive retinal ganglion cells (ipRGC) driven pupil response in young adult humans

摘要: Purpose: ipRGCs signal environmental light, with axons projected to the midbrain control pupil size and circadian rhythms. Post-illumination response (PIPR),a sustained constriction after short wavelength light stimulation is an indirect measure of ipRGC activity. Here, we measured PIPR in young adults different refractive errors using a custom-made optical system. Methods: The system was based on IOVS. 2010; 51: 2764-69. myopic (-3.52 ± 1.73 D, n=17) emmetropic (+0.15 0.31 participants (mean age, 24.31 0.88 years). right eye dilated presented long (red, 625 nm, 2.77 x 1014 photons/cm2/s) (blue, 470 3.17 1s 5s pulses consensual left for 60s following offset. 6s 30s early late area under curve (AUC) were calculated. Results: For all subjects, significantly lower (p<0.001), AUC larger blue compared red suggesting strong response. However, metrics not between myopes emmetropes. Conclusions: Similar previous studies, found no effect error upon PIPR.