Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats

摘要: The therapeutic efficacy of regular physical exercises in an animal model epilepsy and depression comorbidity has been confirmed previously. In the present study, we examined effects endurance training on susceptibility to kainate (KA)-induced status epilepticus (SE), behavioral changes neuronal damage spontaneously hypertensive rats (SHRs). Male SHRs were randomly divided into two groups. One group was exercised a treadmill with submaximal loading for four weeks other sedentary. Immediately after period, SE evoked half sedentary trained by KA, while groups received saline. Basal systolic (SP), diastolic (DP) mean arterial pressure (MAP) all measured at beginning end period. Anxiety, memory depression-like behaviour evaluated month SE. release 5-HT hippocampus using liquid scintillation method analyzed hematoxylin eosin staining. SP MAP decreased comparison initial values. increased resistance KA-induced accompanied elongated latent seizure-free improved object recognition antidepressant effect program. While anticonvulsant positive increase hippocampus, it did not exert neuroprotective activity. Our results indicate that prior exercise is effective means attenuate seizures comorbid hypertension suggesting potential influence hippocampal depression. However, this beneficial impact does prevent development concomitant brain damage.