Short-term effects on antioxidant enzymes and long-term genotoxic and carcinogenic potential of CuO nanoparticles compared to bulk CuO and ionic copper in mussels Mytilus galloprovincialis.
作者： Pamela Ruiz , Alberto Katsumiti , Jose A. Nieto , Jaume Bori , Alba Jimeno-Romero
DOI: 10.1016/J.MARENVRES.2015.07.018
关键词:
摘要: The aim of this work was to study short-term effects on antioxidant enzyme activities and long-term genotoxic carcinogenic potential CuO nanoparticles (NPs) in comparison bulk ionic copper mussels Mytilus galloprovincialis after 21 days exposure 10 μg Cu L(-1). Then, were kept for up 122 clean water. accumulation depended the form metal time. NPs localized lysosomes digestive cells, as confirmed by TEM X ray microanalysis. NPs, produced different glands, overall increasing activities. significantly induced catalase superoxide dismutase Fewer observed gills. Micronuclei frequency increased exposed one organism treated with showed disseminated neoplasia. However, transcription levels cancer-related genes did not vary significantly. Thus, provoked oxidative stress genotoxicity, but further studies are needed determine whether these early events can lead cancer development mussels.
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