Characteristics of and variation in airborne ARGs among urban hospitals and adjacent urban and suburban communities: A metagenomic approach.
作者： Peng He , Yan Wu , Wenzhong Huang , Xinwei Wu , Jiayun Lv
DOI: 10.1016/J.ENVINT.2020.105625
关键词:
摘要: Environmental antibiotic resistance genes (ARGs) have received much attention, while the characteristics of ARGs carried by particulate matter (PM) as a function urban functional region are almost unknown. In this study, PM2.5 and PM10 in an hospital, nearby community nearest suburban were detected using metagenomics. total, 643 ARG subtypes belonging to 22 different types identified. The chloramphenicol exporter gene, sul1, bacA, lnuA most abundant all air samples. hospital exhibited higher abundance richness than communities. profiles depended on region: samples clustered separately, from interspersed among them. representation multidrug quinolone decayed with distance community, indicating that PM may be hotspot for encoding proteins conferring resistance. Airborne environment more closely associated clinically important pathogens those particular, carbapenemase genes, including blaNDM,blaKPC,blaIMP,blaVIM,and blaOXA-48, discovered PM. crAssphage, human host-specific bacteriophage, was applied predict found enriched due anthropogenic pollution but showed no clear evidence selection. drivers complex. Our results highlighted related activities revealed potential hotspot, which could provide new further research consequently mitigate formation airborne transfer risks.
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