Gene frequencies and haplotypic associations within the HLA region in 916 unrelated Japanese individuals
作者： Mitsuo Hashimoto , Tomoko Kinoshita , Miho Yamasaki , Hidenori Tanaka , Tadashi Imanishi
DOI: 10.1111/J.1399-0039.1994.TB02375.X
关键词:
摘要: The gene frequencies and haplotypic associations within the HLA region have been investigated in 916 unrelated Japanese individuals. class I II antigens were studied by conventional serology, alleles, DRB1, DRB3, DQA1, DQB1 DPB1 typed using polymerase-chain reaction amplification sequence-specific oligonucleotide probe (PCR-SSOP) method. Thirty 3 8 15 13 alleles found our population. DR-NJ25, a characteristic antigen native American Asian populations, was observed at 3.0%. This mainly with DRB1*1403 1406 alleles. Twenty-seven out of 30 DRB1 this study had high positive linkage disequilibrium 20 them an exclusive association one specific DQA1-DQB1 combination. strong between HLA-B most striking finding study. Twenty-eight 24 (p < 0.01). other two DRB1*0404 1402, very rare, their 0.2% 0.1%, respectively. data presented population should be useful for studies on anthropology, organ transplantation disease susceptibility.
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