Interleukin-18 genetics and inflammatory disease susceptibility.

摘要: IL18 was mapped to 11q22.2–22.3 in 1998. Owing interleukin (IL)-18's important and novel role immunomodulation, the gene itself has been subject scrutiny, with aim of discovering variants that may impact on disease susceptibility and/or progression. Despite being sequenced numerous times different populations, no non-synonymous have found. However, a number polymorphisms within proximal promoter verified interfere transcription-factor-binding sites. Much subsequent association analyses centred these variants, but yielded consistent results, despite study populations genotyped. recently resequenced its entirety, enabling tagging-single-nucleotide polymorphism (tSNP) methodology be adopted. This approach interesting genetic variation shown affect protein levels, risk. review aims compile reflect data interest published date, focus diseases related aberrant inflammatory control.