Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)
作者： C. T. Dourish , P. H. Hutson , G. Curzon
DOI: 10.1007/BF02412123
关键词:
摘要: The effects of para-chlorophenylalanine pre-treatment (PCPA, 150 mg/kg IP daily for 3 days) on feeding and stereotyped behaviour elicited by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in rats were investigated. PCPA depleted brain 5-hydroxyindoleacetic acid concentrations 90% increased feding during a 2-h day-time test. 8-OH-DPAT (60–4000 μg/kg SC) food intake control animals but decreased PCPA-treated treatment had no effect 8-OH-DPAT-induced locomotion or serotonin-related (i.e. forepaw treading, headweaving, wet dog shakes, etc). Since prevents operation pre-synaptic serotonergic mechanisms, failure to increase suggests that hyperphagia is autoreceptor mediated.
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