Functional analysis of human T-cell leukemia virus type I rex-response element: direct RNA binding of Rex protein correlates with in vivo activity.
作者： C Ballaun , G K Farrington , M Dobrovnik , J Rusche , J Hauber
DOI: 10.1128/JVI.65.8.4408-4413.1991
关键词:
摘要: The human T-cell leukemia virus type I rex gene product plays a critical role in the expression of retroviral structural proteins Gag and Env from incompletely spliced mRNAs. Rex protein acts through cis element (rex-response [RxRE]) which is located U3/R region 3' long terminal repeat present on all I-specific Two domains predicted secondary structure RxRE are crucially important for action vivo as measured by two assay systems. In vitro studies using highly purified recombinant revealed specific direct interaction with radiolabeled sequences. correlation between our results binding to mutant wild-type sequences supports both existence importance this cis-acting RNA sequence function vivo.
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