Dauer Formation Induced by High Temperatures in Caenorhabditis elegans

摘要: Dauer formation in Caenorhabditis elegans is regulated by several environmental stimuli, including a pheromone and temperature. moderately induced as the growth temperature increases from 15 degrees to 25 degrees. Here we show that dauer very strongly at of 27 both wild-type animals mutants such unc-64, unc-31, unc-3, which do not form dauers A stimulus sufficient induce independent pheromone. Analysis previously described reveals number surprising results. Several classes (dyf, daf-3, tax-4, tax-2) are defective lower temperatures reverse their phenotypes constitutively. Epistasis experiments place unc-64 unc-31 different position pathway unc-3. We also uncover new branches detected epistatic gene interactions can quantitative qualitative differences depending on conditions. Finally, discuss some possible ecological implications induction high temperatures.