Decreased Levels of Nasal Nitric Oxide in Children With Midline Neuroanatomical Anomalies: A Possible Connection Between Ciliary Dysfunction and Isolated Nervous System Defects.

摘要: Abstract Objectives Given the involvement of cilia in midline neurodevelopment, we set to determine whether children with neuroanatomical defects have increased prevalence ciliary dysfunction, using nasal nitric oxide measurement, a screening test for primary dyskinesia. Study design We measured levels 26 ages 6-17, congenital central nervous system defects, who are otherwise healthy. evaluated effect variables including: age, gender, and anomaly (brain, spinal cord, or combined) on our measurements. compared results previously established normal range (153.6-509.9 nL/min) cutoff dyskinesia (77 nL/min). Results The overall cohort was 56.5-334.7 nL/min, not having significant effect. mean, 217.7 nL/min, significantly lower than preestablished mean children, 314.51 nL/min ( P Conclusions This is first study report possible association between dysfunction isolated context any known syndrome. suggest that genes cause may also be involved function cilia. Longitudinal studies required investigate whether, abnormal measurements, normalize over time, these suffer from respiratory sequelae.